HOW CBD INTERACTS IN PEOPLE WITH DEMENTIA

HOW CBD INTERACTS IN PEOPLE WITH DEMENTIA

The number of people who suffer from dementia is rapidly increasing. About 45.7 million people have some type of dementia, worldwide. Some medicine is available to treat dementia but awful side effects of nausea and dizziness can occur. The best way one can take care of a loved one with dementia is with constant and extensive care. Since CBD is non-psychoactive and works with receptors within the brain, studies show results that CBD can help with dementia symptoms.

In the first study, mice demonstrate impairment in visual and social recognition from a variety of tests done. Over a course of three weeks the mice were given with CBD. The results show that the chronic CBD treatment reversed the cognitive deficits without displaying any behavior related to anxiety. CBD might be a therapeutic remedy for cognitive deficiencies.

Alzheimer’s Disease

To begin with, Alzheimer’s is a progressive brain disorder where brain cells degenerate and die. The disease is part of the extracellular neuritic plaque of β-amyloid (Aβ), a sticky, chemical protein that builds-up between the nerve cells. Clumps of Aβ can block cell-to-cell signals which results in memory loss and confusion. CBD is shown to protect against Aβ neurotoxicity.

CBD can work as a CB1 receptor agonist to interrupt excitotoxicity, which reduces the glutamine release in the body. Lack of glutamine is not good to our body systems and has a direct effect on your memory. Because glutamine is most commonly found in the neurotransmitter, the sensory neurons send signals from the central nervous system to effectors, including muscles and glands.

The CB2 receptors are mainly in immune cells that work to reduce inflammation. CBD also works as a CB2 receptor agonist to reduce neuroinflammation which leads to plaque removal. Plaques are clusters of Aβ that trigger inflammation and destruct cells activated through your immune system cells.

Huntington’s Disease

In addition, Huntington’s disease creates movement, cognitive and psychiatric disorders based on progressive breakdown of nerve cells in the brain. This is a hereditary disease and currently has no known cure. Movement disorders include involuntary jerking, muscle problems, slow movements, impaired posture, and difficulty with speech. Due to, a cognitive disorder symptoms can be difficulty learning, slow with thoughts and words, and lack of awareness.

The caudate nucleus, putamen and globus pallidus are where cannabinoids in the CB1 receptor will bind to. The caudate nucleus has a major impact on one’s memory or learning; the intake of information. In the front of the brain at the basal nuclei region, the caudate nucleus enteracts with various brain diseases which affect essential functions such as movement and learning. Strong with the caudate nucleus, putamen involves in a feedback loop to that prepares the movement of limbs. Jerky, involuntary movements are symptoms Huntington’s disease has on a person. Globus pallidus involves the regulation of voluntary movement which can also have effects on movement on the subconscious level. Cannabinoids bind to CB2 receptors to exert their efforts in regards to the microglia or the brain cells that clear all cellular debris.

Parkinson’s Disease

Finally, lack of dopamine in the body leads to Parkinson’s disease. Nerve cells in the brain have direct affect from Parkinson’s disease resulting in muscle tremors, sleep problems, rigidity and differences in speech and gait. There is no cure for people who have Parkinson’s disease although treatments are available. So, for those who are looking to find relief of Parkinson’s disease, CBD and other cannabinoids might be able to help.

Cannabinoids do not seems to have an impact on the CB2 receptor; instead cannabinoids react to decrease the substantia nigra and increase dopaminergic projecting areas within the CB1 receptor. Dopamine congregates around the same area known as the substantia nigra to relay messages from the substantia nigra to other parts of the brain that control one’s movements. The cause is a decrease in substantia nigra would affect the communication to and from the brain. Projecting areas are different places of the brain there neurons travel to release dopamine.

It doesn’t matter what type of dementia one suffers from; whether a friend, family member or care-receiver might have, the body’s endocannabinoid system might be able to provide the relief one is looking for without the harsh side effects. There is a lot to still be studied on the effects CBD has on people with dementia but based on preclinical and clinical trials, to date, there could be hope that CBD can help people with dementia.

PURE HEMP CBD NEED-TO-KNOW FACTS

PURE HEMP CBD NEED-TO-KNOW FACTS

Pure hemp CBD is a great alternative for those looking to relieve pain or illness. Research shows that there are many healing effects that come with CBD when it reacts with your endocannabinoid system. Despite what people say, pure hemp CBD does not give you psychoactive effects like THC would. But, CBD does provide additional benefits that can help many.

Pure Hemp CBD Facts

Cannabinoid in the cannabis plant

Of the many cannabinoids in a cannabis plant, cannabidiol or CBD is one of the most dominant. It is not only in the marijuana plant but CBD can also be in industrial hemp. Medical marijuana strains that have low THC but high CBD are taken by people who suffer from various health effects.

Non-psychoactive

Different than THC, CBD does not provide the body or mind with psychoactive effects. This means CBD will not make you feel “high”. Unlike THC which binds to your CB1 receptor, which is responsible for mind-altering effects, CBD does not act directly with the CB1 receptor.

Potential Medical benefits

There are many research studies that focus on the effects of CBD. Although most studies use animals as their test subjects and few have used human patients. CBD works with your endocannabinoid system to release signals to various parts of your body that fix imbalances within the your body. Studies have shown CBD to have the following properties:

  • Anti-inflammatory
  • Antioxidant
  • Anti-nausea
  • Anti-tumoral
  • Antidepressant

Reduce negative drug effect

CBD reduces the negative effects that THC or other drugs might provide someone. It works to reduce the impairment effects THC provides such as; memory loss, anxiety and paranoia.

Application methods

Capsule

Typically comes in a soft-gel or gelatin capsule and have a variety of doses.

Dropper

The dropper is ideal to put in food or to give in smaller dose to a child or pet. A dropper will provide the consumer with more specific medication.

Topical

Topicals are best for muscle pain or arthritis. They are sold in salves, lotions, lip balm, and gels. Also apply our dropper as a topical.

Vape Cartridge

Vape cartridges for CBD are exactly like cartridges for THC. They attach to a battery that will heat what is in the filled chamber. CBD vape juice is also available on the market to fill your own.

Pet treats

Dog food and pet treats are made specifically for pets to give them the healing effects of CBD but without too high of doses.

Effect on what parts of the body

  • Serotonin receptor: sleep, appetite and depression
  • Vanilloid receptor: pain, inflammation and body temperature
  • Adenosine receptor: cardiovascular and neurotransmitters
  • GPR55 receptor: bone density, blood pressure, cancer cell inhibitor
  • Antioxidant: neuroprotection, defense system